Best of ADA China 2026 TOP TALK 第一期丨中外专家解读口服GLP-1RA研究进展

Best of ADA China 2026 TOP TALK 第一期丨中外专家解读口服GLP-1RA研究进展的核心信息是什么?

声明:本内容仅供中国境内(不含港澳台地区)执业的医疗卫生专业人士参考,不构成对任何药物或治疗方案的推荐、广告或宣传。未经授权不得转载或用于其他用途。 参考文献 [1] Pratt E, et al. Diabetes Obes Metab. 2023;25(9):2642-2649. [2] Safety, tolerability, pharmacokin...

声明:本内容仅供中国境内(不含港澳台地区)执业的医疗卫生专业人士参考,不构成对任何药物或治疗方案的推荐、广告或宣传。未经授权不得转载或用于其他用途。 属于「拓麦Diabetes」分类。 本文由 TalkMED 拓麦医学编辑团队审核发布,内容来源清晰、引用完整,符合平台编辑方针和利益冲突披露政策。

本文核心问答

Q1: 该研究的关键数据和临床意义是什么?

未经授权不得转载或用于其他用途。

Q2: 这篇文章的来源和作者资质如何?

发布于2026-06-15。

来源:拓麦Diabetes

声明:本内容仅供中国境内(不含港澳台地区)执业的医疗卫生专业人士参考,不构成对任何药物或治疗方案的推荐、广告或宣传。未经授权不得转载或用于其他用途。

参考文献

[1] Pratt E, et al. Diabetes Obes Metab. 2023;25(9):2642-2649.

[2] Safety, tolerability, pharmacokinetics, and pharmacodynamics of orforglipron: A multiple dose titration study in Chinese participants with obesity or overweight with weight-related comorbidities (Poster Abstract No. 2624-P). Poster presented at the American Diabetes Association Annual Meeting.

[3] Efficacy and safety of Orforglipron vs Placebo Added to Titrated Insulin Glargine in Adults with Long-Standing Type 2 Diabetes: ACHIEVE-5. Presented at: American Diabetes Association 86th Scientific Sessions; 2026 Jun 5-8; New Orleans, LA, USA.

[4] Health-Related Quality of Life (HRQoL) in People with Type 2 Diabetes (T2D) Receiving the Once-Daily, Oral, Non-Peptide GLP-1 RA Orforglipron in ACHIEVE-2 and -3. Presented at: American Diabetes Association 86th Scientific Sessions; 2026 Jun 5-8; New Orleans, LA, USA.

[5] Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. N Engl J Med. 2025;393(13):1209-1221.

[6] Efficacy and safety of once-daily oral orforglipron compared with dapagliflozin in adults with type 2 diabetes (ACHIEVE-2): a multinational, multicentre, randomised, open-label, phase 3 trial. Lancet Diabetes Endocrinol. 2025;13(11):805-816.

[7] Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial. Lancet. 2026;407(10500):1147-1160.

[8] Efficacy and safety of once-daily oral orforglipron in adults with type 2 diabetes inadequately controlled with metformin plus basal insulin (ACHIEVE-5): a multinational, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2026;406(10499):2927-2944.

[9] Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. N Engl J Med. 2025;393(18):1796-1806.

[10] Orforglipron for weight management in adults with obesity and type 2 diabetes (ATTAIN-2): a 72-week, phase 3, randomised, double-blind, placebo-controlled trial. Lancet. 2025;396(10265):2011-2022.

[11] PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes. Diabetes Care. 2019;42(9):1724-1732.

[12] Efficacy and safety of oral semaglutide versus sitagliptin in patients with type 2 diabetes (PIONEER 2): a randomised, double-blind, phase 3a trial. Lancet. 2019;394(10193):193-202.

[13] Oral semaglutide versus empagliflozin in patients with type 2 diabetes uncontrolled on metformin (PIONEER 4): a randomised, double-blind, phase 3a trial. Lancet Diabetes Endocrinol. 2019;7(7):503-513.

[14] Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): a multicentre, open-label, randomised, phase 3a trial. Lancet Diabetes Endocrinol. 2019;7(7):528-539.

[15] Orforglipron and markers of insulin sensitivity and beta-cell function by prediabetes status in adults with obesity: a post hoc analysis of the ATTAIN-1 trial. Poster presented at: American Diabetes Association Annual Meeting. Abstract 1666-P.

 

本文研究方法与设计类型

本研究采用临床试验设计。

引用格式:Best of ADA China 2026 TOP TALK 第一期丨中外专家解读口服GLP-1RA研究进展. 发布日期:2026-06-15. 来源:TalkMED拓麦. URL: https://portal.talkmed.com/news/4080

2026-06-15

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