EADV 2025｜分子特征分析在皮肤病学中的临床意义

洛桑大学医院皮肤科主任Michel Gilliet教授在大会上介绍了关于皮肤病分子特征分析的突破性工作。他的团队开发了一种新方法，利用转录组学来绘制炎症性皮肤病的详细分子"图谱"。

这一创新方法不仅仅是一个研究工具，它已经开始应用于临床实践。它有助于诊断具有挑战性和不明确的病例，例如红皮病和掌跖皮炎，这些疾病通过传统方法往往难以确诊。更重要的是，这种分子图谱能够指导临床医生为每位患者选择最合适的靶向治疗，从而超越传统的"试错"法，迈向精准医疗。通过使治疗与疾病的特定分子特征相匹配，这种方法显著提高了疗效，代表了皮肤病学领域的关键一步。  

Professor Michel Gilliet, Chair of the Department of Dermatology in Lausanne, presented groundbreaking work on the molecular profiling of skin diseases at the congress. His team has developed a novel approach that utilizes transcriptomics to create a detailed molecular "cartography" of inflammatory skin conditions.

This innovative method is not just a research tool; it is already being translated into clinical practice. It aids in diagnosing challenging and ambiguous cases, such as erythroderma and palmoplantar dermatitis, where traditional diagnosis can be difficult. More importantly, this molecular map guides clinicians in selecting the most appropriate targeted therapy for each patient, moving beyond trial-and-error towards precision medicine. By aligning treatment with the specific molecular signature of the disease, this approach significantly enhances therapeutic efficacy and represents a pivotal step forward in dermatology.